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Cancer: Gastric (Stomach) Cancer

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Total 21340 results found since Jan 2013.

Woman diagnoses her own ovarian cancer with Google search
Sadie Rance turns to internet search engine for answers after being told stomach pains and constipation were due to Irritable Bowel Syndrome
Source: Telegraph Health - February 6, 2015 Category: Consumer Health News Tags: search ovarian Irritable Bowel Syndrome Sadie Rance diagnosed Cancer Google Source Type: news

Tratamento de deiscência cirúrgica grave com sistema «Over-the-scope clip»
We report endoscopic treatment success of the dehiscence using “Over-the-Scope Clip” (OTSC) system. Besides the unusual topography of the dehiscence, the uniqueness of this case relies on the new endoscopic approach. OTSC was not conventionally performed directly on the fistula orifice, but upstream in the normal jejunal mucosa, closing the loop at that level. This allowed the exclusion of the most distal segment, including the dehiscence, and subsequent resolution of the fistula and associated loci by secondary intention. The results obtained led to a strike clinical improvement.
Source: GE Jornal Portugues de Gastrenterologia - December 20, 2014 Category: Gastroenterology Source Type: research

Tratamento de deisc ência cirúrgica grave com sistema «Over-the-scope clip»
We report endoscopic treatment success of the dehiscence using “Over-the-Scope Clip” (OTSC) system. Besides the unusual topography of the dehiscence, the uniqueness of this case relies on the new endoscopic approach. OTSC was not conventionally performed directly on the fistula orifice, but upstream in the normal jejunal mucosa, closing the loop at that level. This allowed the exclusion of the most distal segment, including the dehiscence, and subsequent resolution of the fistula and associated loci by secondary intention. The results obtained led to a strike clinical improvement.
Source: GE Jornal Portugues de Gastrenterologia - July 20, 2016 Category: Gastroenterology Source Type: research

Vascular endothelial growth factor gene polymorphisms and gastric cancer risk: a meta-analysis.
CONCLUSION: Our meta-analysis suggests that VEGF-634 G allele carrier may increase gastric cancer risk, whereas the VEGF +1612 G/A G allele and G allele carrier may decrease the risk. No association between+936C/T, -460C/T, -2578C/A, -1154G/A polymorphisms and susceptibility to gastric cancer was found. PMID: 28730780 [PubMed - in process]
Source: Journal of B.U.ON. - July 22, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research

Abstract 4810: Identification of molecular markers of pathological vascular subtypes with differential sensitivity to therapies targeting the VEGF pathway
Therapeutic targeting of the VEGF pathway has not matched the efficacy suggested by preclinical tumor models. To date, the limitations of this form of therapy stem either from inherent or acquired resistance of the tumor vasculature to the reduction of VEGF signaling. Previous studies have described morphological phenotypes of different blood vessel types in human and mouse tumors. Recapitulation of these vascular phenotypes with a surrogate Ad-VEGFA164 model has shown differential sensitivity of these vascular subclasses to inhibitors of the VEGF pathway. The goal of the current study was to identify molecular markers for...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Falcon, B. L., O'Mahony, M., Stewart, J., Liu, J., Nagy, J. A., Xue, Q., Pan, Y., Jeffries, C., Hatten, E., Holzer, T. R., Dvorak, H. F., Nasir, A., Pytowski, B., Benjamin, L., Uhlik, M. T. Tags: Tumor Biology Source Type: research

Transgenically expressed Helicobacter pylori CagA in vascular endothelial cells accelerates arteriosclerosis in mice
Biochem Biophys Res Commun. 2022 Jun 5;618:79-85. doi: 10.1016/j.bbrc.2022.06.010. Online ahead of print.ABSTRACTArteriosclerosis is intimately associated with cardiovascular diseases. Recently, evidence accumulated that infection with Helicobacter pylori cagA-positive strains, which causes gastritis, peptic ulceration, and gastric cancer, is also involved in the development of arteriosclerosis. The cagA-encoded CagA protein is injected into the attached gastric epithelial cells via the type IV secretion system. We previously showed that CagA-containing exosomes are secreted from CagA-injected gastric epithelial cells and ...
Source: Biochemical and Biophysical Research communications - June 18, 2022 Category: Biochemistry Authors: Kamrunnesa Tahmina Narumi Hikawa Atsushi Takahashi-Kanemitsu Christopher Takaya Knight Kengo Sato Fumiko Itoh Masanori Hatakeyama Source Type: research

Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage
Conclusion These results indicated that Lenvatinib inhibited VEGF- and FGF-driven angiogenesis and showed a broad spectrum of antitumor activity with a wide therapeutic window. MVD and pericyte-coverage of tumor vasculature might be biomarkers and suggest cases that would respond for lenvatinib therapy.
Source: Vascular Cell - September 6, 2014 Category: Cytology Source Type: research

A novel vascular-targeting peptide for gastric cancer delivers low-dose TNF α to normalize the blood vessels and improve the anti-cancer efficiency of 5-fluorouracil
This study further investigated the targeting ability of TCP-1 phage and peptide to blood vessels in an orthotopic gastric cancer model in mice and assessed the synergistic anti-cancer effect of 5-fluorouracil (5-FU) with subnanogram TNFα targeted by TCP-1 peptide. In vivo phage targeting assay and in vivo colocalization analysis were carried out to test the targeting ability of TCP-1 phage/peptide. A targeted therapy for improvement of the therapeutic efficacy of 5-FU and vascular function was performed through administration of TCP-1/TNFα fusion protein in this model. TCP-1 phage exhibited strong homing ability to the ...
Source: Peptides - September 29, 2017 Category: Biochemistry Source Type: research

Interaction Between Vascular Endothelial Growth Factor Gene Polymorphism and Smoking on Gastric Cancer Risk in Chinese Han Population
Conclusion: We found that rs10434 -G and rs833061-T alleles, gene- environment interaction between rs10434, and current smoking were all related to increased GC risk.PMID:36091938 | PMC:PMC9454397 | DOI:10.3389/pore.2022.1610495
Source: Pathology Oncology Research - September 12, 2022 Category: Pathology Authors: Longyue Wang Shuaishuai Xiao Yiming Zheng Zefeng Gao Source Type: research

Gastric Cancer Cell-Derived Exosomal GRP78 Enhances Angiogenesis upon Stimulation of Vascular Endothelial Cells
Curr Issues Mol Biol. 2022 Dec 6;44(12):6145-6157. doi: 10.3390/cimb44120419.ABSTRACTExosomes containing glucose-regulated protein 78 (GRP78) are involved in cancer malignancy. GRP78 is thought to promote the tumor microenvironment, leading to angiogenesis. No direct evidence for this role has been reported, however, mainly because of difficulties in accurately measuring the GRP78 concentration in the exosomes. Recently, exosomal GRP78 concentrations were successfully measured using an ultrasensitive ELISA. In the present study, GRP78 concentrations in exosomes collected from gastric cancer AGS cells with overexpression of...
Source: Current Issues in Molecular Biology - December 22, 2022 Category: Molecular Biology Authors: Kanako Iha Akane Sato Hsin-Yi Tsai Hikaru Sonoda Satoshi Watabe Teruki Yoshimura Ming-Wei Lin Etsuro Ito Source Type: research